Open AccessDexmedetomidine versus ketamine infusion to alleviate propofol injection pain: A prospective randomized and double-blind study
Author(s) -
Seema Thukral,
Priyanka Gupta,
Archana Lakra,
Mayank Gupta
Publication year - 2015
Publication title -
indian journal of anaesthesia/indian journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 30
eISSN - 0976-2817
pISSN - 0019-5049
DOI - 10.4103/0019-5049.162987
Subject(s) - medicine , dexmedetomidine , propofol , ketamine , anesthesia , saline , bolus (digestion) , loading dose , incidence (geometry) , general anaesthesia , randomized controlled trial , surgery , sedation , physics , optics
The use of propofol as the most common induction agent and the high prevalence of propofol injection pain (PIP) highlight the significance of finding the ideal combination of drug, dosage and mode of administration of premedicants to alleviate PIP. A number of bolus drugs with variable efficacy have been studied to reduce PIP. The aim of our study was to assess the efficacy of single dose intravenous (IV) infusion of dexmedetomidine 0.5 μg/kg compared with ketamine 0.5 mg/kg to alleviate PIP.