Open AccessComparison of ramosetron with ondansetron for the prevention of post-operative nausea and vomiting in high-risk patients
Author(s) -
Sandip Agarkar,
Aparna Chatterjee
Publication year - 2015
Publication title -
indian journal of anaesthesia/indian journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 30
eISSN - 0976-2817
pISSN - 0019-5049
DOI - 10.4103/0019-5049.154999
Subject(s) - ondansetron , medicine , antiemetic , postoperative nausea and vomiting , nausea , anesthesia , vomiting , incidence (geometry) , physics , optics
Post-operative nausea and vomiting (PONV) has an 80% incidence in high-risk patients. This is despite the availability of several antiemetic drugs. Selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are considered first-line for prophylaxis, ondansetron being the most commonly used agent. Ramosetron, another selective 5-HT3 receptor antagonist, is more potent and longer acting than ondansetron. This study was conducted to evaluate the antiemetic efficacy of ramosetron in comparison with ondansetron in patients at a high risk of PONV.