Open AccessDie kardiorespiratoriese effek van detomidien in die primaat (Papio ursinus)
Author(s) -
H. Bosman
Publication year - 1990
Publication title -
suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie/die suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie
Language(s) - English
Resource type - Journals
eISSN - 2222-4173
pISSN - 0254-3486
DOI - 10.4102/satnt.v9i3.461
Subject(s) - detomidine , ketamine , anesthesia , bradycardia , medetomidine , heart rate , medicine , cardiorespiratory fitness , reflex , xylazine , blood pressure
Detomidine is a novel imidazole derivative with a high affinity for a₂-adrenoceptors. The cardiorespiratory effects of this drug were evaluated in the primate (Papio ursinus) under ketamine anaesthesia. The release of noradrenalin is modulated by a₂-adrenoceptors, and this resulted in a longer duration of anaesthesia when ketamine was combined with detomidine in comparison with ketamine alone. Detomidine caused a marked bradycardia, which was not reflex induced, but probably the result of a decreased sympathetic outflow. Various conducting disturbances were observed in the electrocardiogram, also probably the result of decreased sympathetic tone to the heart. The effect of detomidine on the respiratory system was minimal. Detomidine proved to be a useful drug to use in combination with ketamine for the induction of anaesthesia in primates. It should, however, not be used during cardiovascular studies