Open AccessCombination of glucose transporter inhibitors and oestrone analogues on breast cancer cells
Author(s) -
André van Tonder,
Anna Margaretha Joubert,
Allan Duncan Cromarty
Publication year - 2014
Publication title -
suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie/die suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie
Language(s) - English
Resource type - Journals
eISSN - 2222-4173
pISSN - 0254-3486
DOI - 10.4102/satnt.v33i1.1263
Subject(s) - breast cancer , pharmacology , transporter , cancer , cancer research , cancer cell , cancer cell lines , glucose transporter , medicine , biology , chemistry , computational biology , oncology , biochemistry , gene , insulin
Combinations of chemotherapeutic agents are commonly used in the clinical setting as this allows for a reduction in the dose of each agent, and thus reduced toxicity, with increased therapeutic efficacy. This study proved the feasibility of synergy between two novel oestrone analogues and GLUT inhibitors. The synergistic combinations which have been identified indicate that the different molecular subtypes of breast cancer, as represented by the cell lines used, respond differently to the combination therapy. These differences will be further investigated