In vitro signal transduction mechanism exerted by 2-ethyl-3- O -sulphamoyl-estra-1,3,5(10), 15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MCF-7) and breast non-tumorigenic (MCF-12A) cells | Zendy

Xiao Xing Stander | Zendy; André Stander | Zendy; A.M. Joubert | Zendy

Open Access

<i>In vitro</i> signal transduction mechanism exerted by 2-ethyl-3- O -sulphamoyl-estra-1,3,5(10), 15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MCF-7) and breast non-tumorigenic (MCF-12A) cells

Author(s) -

Xiao Xing Stander,

André Stander,

A.M. Joubert

Publication year - 2012

Publication title -

suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie

Language(s) - German

Resource type - Journals

eISSN - 2222-4173

pISSN - 0254-3486

DOI - 10.4102/satnt.v31i1.343

Subject(s) - in vitro , mechanism (biology) , chemistry , signal transduction , microbiology and biotechnology , stereochemistry , biochemistry , biology , philosophy , epistemology

2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word.

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