Open AccessDie gebruik van mitochondriale DNA-ondersoeke in geregtelik-geneeskundige wetenskappe
Author(s) -
Steve Dawson,
Charles J. Weitz,
M. J. Pitout
Publication year - 1996
Publication title -
suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie/die suid-afrikaanse tydskrif vir natuurwetenskap en tegnologie
Language(s) - English
Resource type - Journals
eISSN - 2222-4173
pISSN - 0254-3486
DOI - 10.4102/satnt.v15i2.635
Subject(s) - mitochondrial dna , biology , identification (biology) , population , genetics , evolutionary biology , computational biology , ancient dna , forensic genetics , dna sequencing , dna , dna profiling , gene , microsatellite , medicine , ecology , allele , environmental health
A variety of methods was developed to characterize mtDNA. The initial aim of these techniques was to try and link diseases with specific mitochondrial defects. As a result of the maternal inheritance trait of mtDNA these techniques facilitate studies of the phylogenetic history and population structure of the human population. It has been shown that mitochondrial DNA typing can be of great value for human identification in forensic cases. The identification of victims of mass-disasters or mass-murders, where human remains can be recovered only after many years have passed, is one of the most challenging fields of forensic identification. By using automated DNA sequencing with fluorescent labels, mitochondrial DNA sequences can be generated rapidly and accurately. Computer software facilitates the rapid comparison of individual and reference sequences