Open AccessObjective: The effects of the application of CO2-baths for the purposes of the specific early functional combined therapy in cases of reflexsympathetic dystrophy should be differentiated.Subjects: Forty patients suffering from acute post-traumatic reflex sympathetic dystrophy in the hand.Design: A four weeks’ omission test was carried out in group B. The resultswere contrasted to group A. The relevant parameters in the process of regeneration were statistically calculated as a chronological serial analysis.Results: In regard of the multi-variable design the results demonstrated highly significant group differences in the case of the progression of regeneration, at which group A was definitely superior to group B. Group B displayed an additional effect of delay. Conclusion: The potential influences with regard to the effects of the CO2-bath are: better organisation of the exercises and superior progression of regeneration. Obviously there are beneficial effects of the combination therapy.