Open AccessPhysiotherapy learners treat patients with Human Immuno-deficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). There is no available published research on physiotherapy learners' opinions about how the South Afican physiotherapy undergraduate program is helping them cope with HIV/AIDS patients. This study determines whether the physiotherapy degree offered at South African Universities, adequately prepares learners to cope with HIV/AIDS patients. Differences in knowledge and attitudes of physiotherapy learners regarding HIV/AIDS, amongst universities is also explored. Two hundred and two senior physiotherapy learners from eight South African universities returned their questionnaires and 55% of these were viable for analysis. A large portion (79%) of learners indicated that the physiotherapy undergraduate degree did not adequately prepare them to cope with HIV/AIDS patients. Learners' knowledge and attitudes regarding HIV/AIDS differed significantly (41% to 73%) amongst universities. Formal lectures on HIV/AIDS significantly affected knowledge (0% -100%) but not attitude towards patients. The role of the physiotherapist, precautions, transmission modes, syndrome stages, counseling and clinical skills were considered critical in the management of HIV/AIDS patients.