Open AccessTuberculosis prevention in HIV-infected pregnant women in South Africa
Author(s) -
Catherine Martin,
Vivian Black
Publication year - 2012
Publication title -
southern african journal of hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.859
H-Index - 18
eISSN - 2078-6751
pISSN - 1608-9693
DOI - 10.4102/sajhivmed.v13i4.113
Subject(s) - medicine , nevirapine , tuberculosis , pregnancy , human immunodeficiency virus (hiv) , isoniazid , antiretroviral therapy , psychological intervention , tb treatment , obstetrics , pediatrics , immunology , viral load , psychiatry , pathology , biology , genetics
The high burden of HIV and tuberculosis (TB) among pregnant women in South Africa contributes to a high maternal mortality rate. Isoniazid preventive therapy (IPT) is recommended for the prevention of active TB in HIV-infected individuals, including pregnant women. However, there are few data regarding IPT use in the latter, with concern regarding the concurrent use of IPT with nevirapine in pregnancy, as both treatments are hepatotoxic. The benefit and safety of IPT in HIV-infected pregnant women has not been established. We recommend a simplification of HIV and TB interventions by providing triple antiretroviral therapy to all HIV-infected pregnant women