Open AccessAbacavir: it’s use and hypersensitivity
Author(s) -
Helena Rabie,
Kristin Lorenc Henning,
Pierre Schoeman,
Nico de Villiers,
G. H. J. Pretorius,
Mark F. Cotton
Publication year - 2009
Publication title -
southern african journal of hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.859
H-Index - 18
eISSN - 2078-6751
pISSN - 1608-9693
DOI - 10.4102/sajhivmed.v10i4.265
Subject(s) - abacavir , medicine , stavudine , zidovudine , nucleoside reverse transcriptase inhibitor , reverse transcriptase inhibitor , reverse transcriptase , didanosine , nucleoside analogue , pharmacology , virology , antiretroviral therapy , human immunodeficiency virus (hiv) , nucleoside , viral disease , viral load , polymerase chain reaction , stereochemistry , genetics , biology , gene , chemistry
Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first and second line therapy as well as a substitute for Stavudine and Zidovudine for toxicity. Although safe and well tolerated, a life threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes especially HLA-B*5701