Open AccessUse of angiotensin receptor – neprilysin inhibitors in heart failure: a paradigm shift
Author(s) -
Mohamed Omar Em Irhuma,
Muhammed Vally
Publication year - 2016
Publication title -
south african family practice
Language(s) - English
Resource type - Journals
eISSN - 2078-6204
pISSN - 2078-6190
DOI - 10.4102/safp.v58i5.4524
Subject(s) - heart failure , ejection fraction , medicine , neprilysin , cardiology , angiotensin converting enzyme , management of heart failure , pharmacotherapy , intensive care medicine , blood pressure , enzyme , biochemistry , chemistry
Heart failure is a clinical syndrome responsible for at least one-third of hospitalisations amongst cardiac patients, with escalating mortality and healthcare costs on both public and private health care. Both prevalence and incidence of heart failure increase steeply with advancing age, making it a growing public health problem. Pathophysiologically, heart failure clinically presents in two common forms: heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. The cornerstone of heart failure management includes the use of angiotensin-converting enzyme inhibitors. A recently developed pharmacotherapy that inhibits both the angiotensin receptor and the enzyme neprilysin has shown promise in the management of heart failure with reduced ejection fraction. This article will highlight the impact of this new therapy and its potential use in heart failure with reduced ejection fraction.