Open AccessEvaluation of hydroxypropyl-b-cyclodextrin in the treatment of aldicarb poisoning in rats : short communication
Author(s) -
R.S. Verster,
Charl P. Botha
Publication year - 2004
Publication title -
journal of the south african veterinary association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 31
eISSN - 2224-9435
pISSN - 1019-9128
DOI - 10.4102/jsava.v75i4.480
Subject(s) - aldicarb , cyclodextrin , chemistry , pharmacology , chromatography , medicine , biology , pesticide , agronomy
Cyclodextrins are ring-shaped oligosaccharides with a hydrophilic exterior and a hydrophobic interior. The interior cavity is capable of complexing fat-soluble molecules small enough to fit inside. Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-beta-cyclodextrin as treatment of aldicarb poisoning in rats. Survival times in the majority of rats dosed with aldicarb and receiving intravenous cyclodextrin were longer compared with the control rats only dosed with aldicarb per os.