Open AccessThe use of liposomal amphotericin B in the management of Xylohypha bantiana mycosis in a dog
Author(s) -
Andrew L. Leisewitz,
C. Rademeyer,
Jacques Picard
Publication year - 2002
Publication title -
journal of the south african veterinary association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 31
eISSN - 2224-9435
pISSN - 1019-9128
DOI - 10.4102/jsava.v73i2.562
Subject(s) - amphotericin b , drug , nephrotoxicity , antifungal , biology , medicine , pharmacology , microbiology and biotechnology , kidney
Xylohypha bantiana is a rare neurotropic fungal infection reported in humans, dogs and cats. In dogs it has only been identified on post mortem examination and thus no successful treatments have previously been reported. Amphotericin B is a potent antifungal drug with a low therapeutic index because of its nephrotoxicity. Liposomal encapsulation of the drug has resulted in much safer use in humans. This article reports a case of Xylohypha bantiana infection in a dog that was diagnosed antemortally and managed with liposomal amphotericin B, which resulted in the prolongation of quality of life for an infection that invariably results in rapid death.