Open AccessEpstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression
Author(s) -
Jude Ogechukwu Okoye,
Anthony Ajuluchukwu Ngokere,
Charles Chinedum Onyenekwe,
Olaposi Idowu Omotuyi,
Deborah I. Dada
Publication year - 2021
Publication title -
african journal of laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 11
eISSN - 2225-2010
pISSN - 2225-2002
DOI - 10.4102/ajlm.v10i1.975
Subject(s) - herpes simplex virus , virus , virology , microrna , reverse transcriptase , human papillomavirus , polymerase chain reaction , real time polymerase chain reaction , biology , reverse transcription polymerase chain reaction , gene , gene expression , medicine , genetics
This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.