Open AccessOmega-3 and Omega-6 Polyunsaturated Fatty Acids in Bipolar Disorder
Author(s) -
Erika F.H. Saunders,
Christopher E. Ramsden,
Mostafa S. Sherazy,
Alan J. Gelenberg,
John M. Davis,
Stanley I. Rapoport
Publication year - 2016
Publication title -
the journal of clinical psychiatry/the journal of clinical psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 207
eISSN - 1534-8628
pISSN - 0160-6689
DOI - 10.4088/jcp.15r09925
Subject(s) - bipolar disorder , mania , polyunsaturated fatty acid , young mania rating scale , treatment of bipolar disorder , hypomania , medicine , eicosapentaenoic acid , psychiatry , fatty acid , chemistry , lithium (medication) , biochemistry
There is growing evidence that inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the data on PUFAs as biomarkers in bipolar disorder and n-3 PUFA used as treatment for bipolar disorder.