Open AccessIMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION
Author(s) -
Emanuele Focà,
Benedetta Fumarola
Publication year - 2022
Publication title -
mediterranean journal of hematology and infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 31
ISSN - 2035-3006
DOI - 10.4084/mjhid.2022.016
Subject(s) - medicine , viremia , cohort , human immunodeficiency virus (hiv) , lymphocyte , incidence (geometry) , immunology , cart , cohort study , mechanical engineering , physics , optics , engineering
"IMMUNOLOGICAL EVOLUTION OF A COHORT OF HIV-2 INFECTED PATIENTS: PECULIARITIES OF AN UNDERESTIMATED INFECTION"Human Immunodeficiency Virus type 2 (HIV-2) affects a minority of patients in Italy; nevertheless, the increasing migratory flow from higher prevalence areas led to the spread of this virus into our Country. We evaluate clinical, viro-immunological and therapeutic characteristics of patients with HIV-2 infection and HIV-1/HIV-2 dual-infection and the early treatment impact on overall survival and incidence of AIDS event.Methods: We retrospectively analyzed all HIV-2 and HIV-1/HIV-2 positive patients followed in a large Italian clinic from January 1987 to December 2020. We recorded demographic, viro-immunological, clinical and therapeutics data. We performed a descriptive analysis followed by a longitudinal analysis to explore the factors associated with CD4+ lymphocyte trend; lastly, we studied in a multivariable model the possible predictors of death and AIDS in our cohort.Results: 32 subjects were enrolled, 17 (53%) HIV-2 infected and 15 (46.8%) HIV-1/HIV-2 dual-infected; 12 patients were lost to follow up, while 3 died. We found a lack of HIV-2 viremia in 12/32 subjects (37.5%).Most of the patients at baseline had a good viro-immunological profile with HIV-2 RNA 200 cell/mcl.