Open AccessCoexistence of T-Large Granular Lymphocyte Leukemia and Peripheral T Cell Lymphoma-NOS with indolent behaviour
Author(s) -
Luca Guarnera,
Valentina Boldrini,
Gianmario Pasqualone,
C Cimino,
Elisa Meddi,
Roberta Laureana,
Donata Trivigno,
Giovanni Del Poeta,
Alessandro Mauriello,
Lucia Anemona,
Massimiliano Postorino,
Maria Cantonetti
Publication year - 2022
Publication title -
mediterranean journal of hematology and infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 31
ISSN - 2035-3006
DOI - 10.4084/mjhid.2022.006
Subject(s) - medicine , lymphoma , not otherwise specified , leukemia , peripheral t cell lymphoma , t cell , hairy cell leukemia , lymphocyte , immunology , pathology , immune system
T-cell lymphomas and leukemias are highly heterogeneous groups of rare disorders. We report a case of a 68-year-old man patient who develops two different T-cell neoplasms (Large Granular Lymphocyte Leukemia [LGLL] in 2018 and Peripheral T-cell non-Hodgkin lymphoma not otherwise specified [PTCL-NOS] in 2019) with a previous diagnosis of B-cell marginal zone lymphoma in 2010, treated with two lines of chemo-immunotherapy. The coexistence of these different T-cell neoplasms is rarely reported in literature and, moreover, is usually described as an LGLL transformation into PTCL-NOS; differently from these examples, herein the simultaneous conditions appear to be driven by different T-cell clones. Furthermore, the PTCL-NOS had a quite unusual behaviour, with a good disease control without intensive treatment. Because of these features, it could belong to a subgroup of indolent PTCL-NOS, not yet described in the WHO classification of T-cell neoplasms, which could benefit of less aggressive treatment.