Rubella associated with hemophagocytic syndrome. First report in a male and review of the literature | Zendy

Makram Koubâa | Zendy; Chakib Marrakchi | Zendy; I. Mâaloul | Zendy; Saloua Makni | Zendy; Lamia Beraajah | Zendy; Moez Elloumi | Zendy; Boussaima Hammami | Zendy; D. Lahiani | Zendy; T. Boudawara | Zendy; Mounir Ben Jemâa | Zendy

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Rubella associated with hemophagocytic syndrome. First report in a male and review of the literature

Author(s) -

Makram Koubâa,

Chakib Marrakchi,

I. Mâaloul,

Saloua Makni,

Lamia Beraajah,

Moez Elloumi,

Boussaima Hammami,

D. Lahiani,

T. Boudawara,

Mounir Ben Jemâa

Publication year - 2012

Publication title -

mediterranean journal of hematology and infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.682

H-Index - 31

ISSN - 2035-3006

DOI - 10.4084/mjhid.2012.050

Subject(s) - hemophagocytosis , medicine , pancytopenia , rubella , rash , immunology , dermatology , bone marrow , cervical lymphadenopathy , pediatrics , pathology , vaccination , measles , disease

A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence of malignant cells. Anti rubella IgM antibody were positive and the IgG titers increased from 16 to 50 UI/mL in 3 days. Therefore, he was diagnosed to have rubella-associated hemophagocytic syndrome. We report herein the first case in a man and the sixth case of rubella-associated hemophagocytic syndrome in the literature by search in Pub Med till March 2012.

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