Open AccessRubella associated with hemophagocytic syndrome. First report in a male and review of the literature
Author(s) -
Makram Koubâa,
Chakib Marrakchi,
I. Mâaloul,
S. Makni,
Lamia Beraajah,
Moez Elloumi,
B. Hammami,
D. Lahiani,
T. Boudawara,
Mounir Ben Jemâa
Publication year - 2012
Publication title -
mediterranean journal of hematology and infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 31
ISSN - 2035-3006
DOI - 10.4084/mjhid.2012.050
Subject(s) - hemophagocytosis , medicine , pancytopenia , rubella , rash , immunology , dermatology , bone marrow , cervical lymphadenopathy , pediatrics , pathology , vaccination , measles , disease
A 22-year-old man was admitted to our hospital because of fever, skin rash and epistaxis. Physical examination revealed fever (39.5°C), generalized purpura, lymphadenopathy and splenomegaly. Blood tests showed pancytopenia. Bone marrow aspiration and biopsy showed hemophagocytosis with no evidence of malignant cells. Anti rubella IgM antibody were positive and the IgG titers increased from 16 to 50 UI/mL in 3 days. Therefore, he was diagnosed to have rubella-associated hemophagocytic syndrome. We report herein the first case in a man and the sixth case of rubella-associated hemophagocytic syndrome in the literature by search in Pub Med till March 2012.