Open AccessCoexisting Pulmonary Tuberculosis and Mucormycosis in a Patient with Aplastic Anemia Post Allogenic Stem Cell Transplantion
Author(s) -
Sanjeev Kumar Sharma,
Narendra Agrawal,
A. S. Mukherjee,
Tulika Seth,
Pravas Mishra,
Immaculata Xess,
Manoranjan Mahapatra,
Sanjay Sharma
Publication year - 2011
Publication title -
mediterranean journal of hematology and infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 31
ISSN - 2035-3006
DOI - 10.4084/mjhid.2011.036
Subject(s) - medicine , mucormycosis , aplastic anemia , immunosuppression , tuberculosis , stem cell , hematopoietic stem cell transplantation , transplantation , surgery , immunology , pathology , bone marrow , biology , genetics
Patients post allogenic stem cell trasplantation are at increased risk of infection owing to immunocompromised state. Other than bacterial and viral infections, patients are at increased risk of fungal and mycobacterial infections. Infection with mucormycosis is rare but dreaded infection and requires aggressive management. Tubercular infection can also complicate post transplant period and risk of infection is high in endemic countries. We report a case of aplastic anemia who following allogenic stem cell transplantation developed combined infection with both tuberculosis and mucormycosis. Isolated infections by tuberculosis and mucormycosis have been reported in transplant recipients but simultaneous infection with both mucormycosis and tuberculosis in transplant recipient has not yet been reported. Anti-tubercular drugs cause interaction with immunosuppressive and anti-fungal drugs and management of such patients is a therapeutic challenge, paticularly in areas where tuberculosis is endemic