Open AccessCarbapenem non-susceptible Klebsiella pneumoniae
Author(s) -
Andrea Rocchetti
Publication year - 2013
Publication title -
working paper of public health
Language(s) - English
Resource type - Journals
ISSN - 2279-9761
DOI - 10.4081/wpph.2013.6741
Subject(s) - meropenem , klebsiella pneumoniae , imipenem , medicine , carbapenem , antibiotics , microbiology and biotechnology , antimicrobial stewardship , biology , antibiotic resistance , biochemistry , escherichia coli , gene
Purpose: This work aims at studying Carbapenem-resistant Klebsiella pneumoniae, which has recently been reported as a new, multidrug-resistant nosocomial pathogen in several hospitals from various Italian regions. Methods: Through Micronet, a new Italian sentinel laboratory-based surveillance network, researchers studied the trend of non-susceptibility of K. pneumoniae to selected carbapenems (imipenem and/or meropenem) in 14 of the 15 hospitals participating in the network. Results: Analysis of data from 1 January 2009 to 30 April 2012 revealed a statistically significant increasing trend (p<0.01) in the proportion of carbapenem non-susceptible K. pneumoniae isolates from clinical specimens (from 2.2 % in 2009 to 19.4% in 2012). The increase in the proportion of non-susceptibility was very large for isolates from the respiratory tract (from 5.3% in 2009 to 38.5% in 2012) and blood (from 5.4% in 2009 to 29.2% in 2012). Conclusions: The results demonstrate the urgent need in Italy for infection control, guidelines, antibiotic stewardship programmes and utilisation of surveillance systems, such as Micronet, which are capable of receiving data from hospitals in real time for many pathogens and types of clinical specimens.