Open AccessTime of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations
Author(s) -
Daniele Porru,
Valentina Bobbi,
Carmelo Di Franco,
Alessandra Viglio,
Mattia Novario,
Carmine Tinelli,
Bárbara Gardella,
Rossella E. Nappi,
Arsenio Spinillo,
Marco Paulli,
B. Rovereto
Publication year - 2017
Publication title -
urogynaecologia international journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 7
eISSN - 2038-8314
pISSN - 1121-3086
DOI - 10.4081/uij.2017.201
Subject(s) - interstitial cystitis , medicine , cystoscopy , bladder pain syndrome , urology , urothelium , biopsy , lesion , urinary bladder , pathology , urinary system
The aim was to find out whether a correlation exists between denudation of urothelium and time of symptom onset in patients with bladder pain syndrome/interstitial cystitis (BPS/IC), and to search a correlation between impact of symptoms evaluated with ICSI-ICPI and the presence of comorbid conditions associated with BPS/IC. Ninety-seven consecutive patients underwent cystoscopy under general anesthesia to classify those cases suspected of being affected from BPS/IC. Three cold bladder biopsies were taken including detrusor muscle. Statistical analysis showed significant correlation between IC/BPS duration and the presence of Hunner’s lesions (P<0.023). Hunner’s lesion with cystoscopy and histological evidence of urothelial denudation with bladder biopsy appear to be items related to IC/BPS duration. Thus an early diagnosis allows to start an appropriate therapeutic approach and prevent a more severe evolution of this multifaceted painful syndrome. Our study shows a correlation between time of symptom onset and evidence of urothelial denudation and with detrusor mast cell count in the whole group of patients. IC/BPS duration seem to correlate with the presence of associated diseases.