Open AccessAntibacterial and antiviral potential of neuropeptides
Author(s) -
Carla Zannella,
Debora Stelitano,
Veronica Folliero,
Luciana Palomba,
Tiziana Francesca Bovier,
Roberta Astorri,
Annalisa Chianese,
Marcellino Monda,
Massimiliano Galdiero,
Gianluigi Franci
Publication year - 2019
Publication title -
translational medicine reports
Language(s) - English
Resource type - Journals
ISSN - 2532-1250
DOI - 10.4081/tmr.8142
Subject(s) - antimicrobial , context (archaeology) , antimicrobial peptides , microbiology and biotechnology , escherichia coli , staphylococcus aureus , klebsiella pneumoniae , salmonella , biology , bacteria , chemistry , biochemistry , paleontology , genetics , gene
The emergence of multidrug resistant bacteria is a global health threat and the discovery of new antimicrobial agents is an absolute priority. In this context endogenous peptides are emerging as novel potential candidates. In this work, we assessed the antimicrobial effects of orexins and ghrelin neuropeptides against gram-negative (Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae) and gram-positive (Staphylococcus aureus) bacteria. Orexin-B and ghrelin showed a potent bactericidal effect at concentration equal to or greater than 25 μg/ml. No antimicrobial activity has been observed for orexin-A. Furthermore, we investigated the antiviral proprieties of the three peptides against herpes simplex virus 1 (HSV-1). We found that orexin-B, but not orexin-A is effective for HSV-1 infectivity inhibition.