BIOMOLECOLE DA BASIDIOMICETI COME SORGENTE DI POTENZIALI NUOVI FARMACI | Zendy

Gianluca Nasini | Zendy

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BIOMOLECOLE DA BASIDIOMICETI COME SORGENTE DI POTENZIALI NUOVI FARMACI

Author(s) -

Gianluca Nasini

Publication year - 2012

Publication title -

istituto lombardo - accademia di scienze e lettere - rendiconti di scienze

Language(s) - English

Resource type - Journals

eISSN - 2384-986X

pISSN - 1974-6989

DOI - 10.4081/scie.2012.129

Subject(s) - stereochemistry , chemistry , bacteria , isolation (microbiology) , microbiology and biotechnology , helicobacter pylori , biology , biochemistry , genetics

We reported the isolation and structural characterization of a new biogenetical related compounds, produced in cultures by various strains of Basidiomycetes of the genera Armillaria, Laurilia, Clitocybe and Clavicorona . The isolated metabolites are sesquiterpenoids containing the protoilludane ring system and are even correlated with some biological activity and biogenetic steps. We have analyzed the chemistry of the melleolides, sulcatines, tsugicolines and clavilactones. In particular, the spirolaxine, isolated from cultures of Sporotrichum laxum, is active on the bacterium Helicobacter pylori and is a potent inhibitor of angiogenesis. Its structure was determined on the basis of chemical and spectroscopic evidence and confirmed by X-ray analysis.

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