Open AccessBiclonal gammopathy of undetermined significance in a patient with systemic lupus erythematosus and antiphospholipid syndrome
Author(s) -
Vincenzo Bruzzese,
Palma Scolieri,
Jessica Pepe
Publication year - 2022
Publication title -
reumatismo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 25
eISSN - 2240-2683
pISSN - 0048-7449
DOI - 10.4081/reumatismo.2021.1431
Subject(s) - medicine , monoclonal gammopathy of undetermined significance , concomitant , antiphospholipid syndrome , amyloidosis , dermatology , immunology , antibody , lupus erythematosus , gammopathy , monoclonal , pathology , monoclonal antibody
The case of a patient suffering from systemic lupus erythematosus with associated antiphospholipid antibody syndrome is described. In this patient, on protein electrophoresis, two monoclonal immunoglobulin G λ and k peaks were seen, defining a condition of biclonal gammopathy of undetermined significance (BGUS). This condition is extremely rare, especially in chronic inflammatory rheumatic diseases. The criteria of a BGUS are defined. We also underline how this condition can be the expression of a concomitant unrecognized cancer, a possible amyloidosis or an infectious process.