Open AccessLate onset systemic sclerosis with seronegativity: a rare presentation of an uncommon disease
Author(s) -
Disha Saxena,
Deepali Jain,
Manish Yadav,
Kalpana Giri,
Tribhuvan Pal Yadav,
Pramod Jain
Publication year - 2019
Publication title -
reumatismo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 25
eISSN - 2240-2683
pISSN - 0048-7449
DOI - 10.4081/reumatismo.2019.1170
Subject(s) - medicine , anti nuclear antibody , antibody , connective tissue disease , systemic disease , scleroderma (fungus) , immunology , disease , autoantibody , progressive systemic sclerosis , fibrosis , pathology , multisystem disease , dermatology , autoimmune disease , inoculation
Systemic sclerosis (SSc) is an uncommon connective tissue disorder characterized by multisystem involvement with fibrosis of skin and internal organs. Antibody formation is one of the hallmarks of SSc. Antinuclear antibodies (ANA) are positive in 97% of patients with SSc. We report a rare case where the patient was negative for ANA, Anti-topoisomerase I, Anti-centromere and Anti-RNA polymerase III antibodies.