Open AccessSubpopulations of anti-β2glycoprotein I antibodies with different pathogenic potential: fine specificity against the domains of β2glycoprotein I
Author(s) -
Laura Andréoli,
Cecilia Nalli,
Mario Motta,
Gary L. Norman,
Walter L. Binder,
Monica Nuzzo,
Micol Frassi,
Andrea Lojacono,
Tadej Avčin,
Pier Luigi Meroni,
Anǵela Tincani
Publication year - 2011
Publication title -
reumatismo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 25
eISSN - 2240-2683
pISSN - 0048-7449
DOI - 10.4081/reumatismo.2010.189
Subject(s) - medicine , asymptomatic , antibody , immunology , antiphospholipid syndrome , pathogenesis , atopic dermatitis , antigen
Anti-β₂glycoprotein I antibodies (a-β₂GPI) are a laboratory criterion for the antiphospholipid syndrome (APS) and were demonstrated to be involved in the pathogenesis of APS. However, they can also be detected in asymptomatic subjects. It has been suggested that a-β₂GPI against Domain1 (D1) associate with thrombosis, while those recognizing Domain4/5 (D4/5) have been identified in non-thrombotic conditions. We evaluate the specificity of a-β₂GPI in different clinical situations.