Open AccessSjogren’s syndrome: apoptosis by anti-SSA and anti-SSB antibodies
Author(s) -
P Scagliusi,
Mario D'Amore,
Simona D’Amore,
Alessandro Scagliusi
Publication year - 2011
Publication title -
reumatismo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 25
eISSN - 2240-2683
pISSN - 0048-7449
DOI - 10.4081/reumatismo.2006.165
Subject(s) - fas ligand , perforin , granzyme , granzyme b , fas receptor , medicine , cytotoxic t cell , apoptosis , immunology , antibody , proteases , autocrine signalling , programmed cell death , cancer research , immune system , t cell , receptor , biology , cd8 , in vitro , biochemistry , enzyme
The pathogenesis of the Sjogren’s Syndrome (SjS) has not yet been completely defined. However, the cell-mediated immunity plays an important role and the apoptosis of the ductal and acinar epithelial cells is responsible of the glandular tissue damage, through the cytotoxic T-cells, particularly of the CD4+ subpopulation, by the release of proteases (such as perforin and granzyme B) and by the interaction of the Fas Ligand (FasL; CD95L) of the T-lymphocytes, with the Fas (Apo-1; CD95) of the epithelial cells. The apoptotic death of the epithelial cells is the autocrine Fas/FasL interaction also. The anti-SSA and anti-SSB antibodies are the immunological markers of the Sjogren’s syndrome, but it is not yet understood if they have pathogenetic implications...