Open AccessAmyloidoses as seen by the Rheumatologist
Author(s) -
J C Gerster
Publication year - 2011
Publication title -
reumatismo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 25
eISSN - 2240-2683
pISSN - 0048-7449
DOI - 10.4081/reumatismo.2001.193
Subject(s) - amyloidosis , medicine , beta 2 microglobulin , amyloid fibril , transthyretin , amyloid (mycology) , extracellular , pathology , fibril , al amyloidosis , aa amyloidosis , immunology , disease , familial mediterranean fever , antibody , biochemistry , immunoglobulin light chain , amyloid β , chemistry
Amyloidosis is due to extracellular deposition in various organs and tissues of amorphous materials made of protein fibrils, whose thickness is 10 nm. Seventeen different amyloid fibrils are known (1). Amyloidosis can be localised or systemic. There are 4 systemic amyloidoses (2): Familial amyloidosis with mutated transthyretin. Primary, paraprotein associated, amyloidosis AL. Secondary AA amyloidosis in long- standing inflammation. β2-microglobulin..