Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy | Zendy

Diana Fridlyand | Zendy; Caroline Wilder | Zendy; E. Leila Jerome Clay | Zendy; Bruce C. Gilbert | Zendy; Betty S. Pace | Zendy

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Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy

Author(s) -

Diana Fridlyand,

Caroline Wilder,

E. Leila Jerome Clay,

Bruce C. Gilbert,

Betty S. Pace

Publication year - 2017

Publication title -

pediatric reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.297

H-Index - 19

ISSN - 2036-7503

DOI - 10.4081/pr.2017.6984

Subject(s) - medicine , stroke (engine) , disease , pediatrics , incidence (geometry) , cerebral infarction , magnetic resonance imaging , vascular disease , retrospective cohort study , hemoglobinopathy , ischemia , radiology , mechanical engineering , physics , optics , engineering

Children with hemoglobin SC (HbSC) disease suffer a significant incidence of silent cerebral infarcts but stroke is rare. A 2-year-old African American boy with HbSC disease presented with focal neurologic deficits associated with magnetic resonance imaging evidence of cerebral infarction with vascular abnormalities. After the acute episode he was treated with monthly transfusions and subsequently transitioned to hydroxyurea therapy. The benefits of hydroxyurea as a fetal hemoglobin inducer in HbSC disease, to ameliorate clinical symptoms are supported by retrospective studies. This case highlights the rare occurrence of stroke in a child with HbSC disease and the use of hydroxyurea therapy

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