Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma | Zendy

Stefano Pileri | Zendy; Claudio Agostinelli | Zendy; Francesco Bacci | Zendy; Elena Sabattini | Zendy; Carlo Sagramoso | Zendy; Brunangelo Falini | Zendy; Pier Paolo Piccaluga | Zendy

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Pathobiology of ALK-Negative Anaplastic Large Cell Lymphoma

Author(s) -

Stefano Pileri,

Claudio Agostinelli,

Francesco Bacci,

Elena Sabattini,

Carlo Sagramoso,

Brunangelo Falini,

Pier Paolo Piccaluga

Publication year - 2011

Publication title -

pediatric reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.297

H-Index - 19

ISSN - 2036-7503

DOI - 10.4081/pr.2011.s2.e5

Subject(s) - anaplastic large cell lymphoma , medicine , lymphoma , anaplastic lymphoma kinase , cancer research , pathology , oncology , malignant pleural effusion , lung cancer

The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented

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