Open AccessHuman papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America
Author(s) -
Antônio Carlos de Oliveira,
Israel Carlos Cavalcanti De Lima,
Vitor Marcelo Frez Marques,
Wudson Henrique Alves de Araújo,
Chrystiano de Campos Ferreira
Publication year - 2022
Publication title -
oncology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.637
H-Index - 21
eISSN - 1970-5565
pISSN - 1970-5557
DOI - 10.4081/oncol.2022.552
Subject(s) - medicine , human papillomavirus , meta analysis , head and neck cancer , cancer , basal cell , oncology , head and neck squamous cell carcinoma , squamous cell cancer , oral cavity , medline , web of science , papillomaviridae , cervical cancer , dentistry , political science , law
Background: Some studies have addressed the prevalence of human papillomavirus (HPV) in head and neck cancer in South America; however, no studies have systematically gathered prevalence and conducted a meta-analysis.
Aim: This study aims to estimate the prevalence of HPV in oral and oropharyngeal squamous cell carcinomas in South America.
Methods: We performed a systematic review and meta-analysis using the following databases: PubMed, Embase, Lilacs, Medline, Scopus, and Web of Science. Data were extracted and analyzed using random-effects models to estimate the pooled prevalence of HPV.
Results: We identified 209 nonduplicated studies, of which 38 were selected. The overall prevalence of HPV was 24.31% (95% CI 16.87–32.64; I2 = 96%, pheterogeneity <0.001). HPV prevalence in oropharyngeal cancer was 17.9% (95% CI 7.6–31.4; I2 = 96%, pheterogeneity <0.001) and that in oral cavity cancer was 23.19% (95% CI 14.94–32.63; I2 = 94%, pheterogeneity <0.001).
Conclusions: We found an overall prevalence of HPV in 24.31% of oral and oropharyngeal squamous cell carcinomas in South American patients. The prevalence of HPV was 17.9% for oropharyngeal cancer and 23.19% for oral cavity cancer.