Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases | Zendy

Luigi Rossi | Zendy; Angelo Zullo | Zendy; Federica Zoratto | Zendy; Anselmo Papa | Zendy; Martina Strudel | Zendy; M. Colonna | Zendy; Federica Tomao | Zendy

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Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

Author(s) -

Luigi Rossi,

Angelo Zullo,

Federica Zoratto,

Anselmo Papa,

Martina Strudel,

M. Colonna,

Federica Tomao

Publication year - 2012

Publication title -

oncology reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.637

H-Index - 21

eISSN - 1970-5565

pISSN - 1970-5557

DOI - 10.4081/oncol.2012.179

Subject(s) - medicine , colorectal cancer , chemotherapy , adjuvant , adjuvant chemotherapy , oncology , metastasis , resection , cancer , surgery , general surgery , breast cancer

Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.

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