Open AccessMolecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
Author(s) -
Julie Scholler,
Dominique Levêque
Publication year - 2011
Publication title -
oncology reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.637
H-Index - 21
eISSN - 1970-5565
pISSN - 1970-5557
DOI - 10.4081/oncol.2011.20
Subject(s) - medicine , pharmacokinetics , pharmacology , drug , transporter , gene , biology , biochemistry
This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.