18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging evaluation of chorea | Zendy

Nobuyuki Ishii | Zendy; Hitoshi Mochizuki | Zendy; Miyuki Miyamoto | Zendy; Yuka Ebihara | Zendy; Kazutaka Shiomi | Zendy; Masamitsu Nakazato | Zendy

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18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging evaluation of chorea

Author(s) -

Nobuyuki Ishii,

Hitoshi Mochizuki,

Miyuki Miyamoto,

Yuka Ebihara,

Kazutaka Shiomi,

Masamitsu Nakazato

Publication year - 2018

Publication title -

neurology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.39

H-Index - 16

ISSN - 2035-8377

DOI - 10.4081/ni.2018.7780

Subject(s) - medicine , chorea , positron emission tomography , magnetic resonance imaging , nuclear medicine , brain positron emission tomography , radiology , positron emission , nuclear magnetic resonance , medical physics , preclinical imaging , pathology , physics , disease , microbiology and biotechnology , biology , in vivo

Chorea is thought to be caused by deactivation of the indirect pathway in the basal ganglia circuit. However, few imaging studies have evaluated the basal ganglia circuit in actual patients with chorea. We investigated the lesions and mechanisms underlying chorea using brain magnetic resonance imaging (MRI) and F-fluorodeoxyglucose positron emission tomography (FDG-PET). This retrospective case series included three patients with chorea caused by different diseases: hyperglycemic chorea, Huntington's disease, and subarachnoid hemorrhage. All the patients showed dysfunction in the striatum detected by both MRI and FDG-PET. These neuroimaging findings confirm the theory that chorea is related to an impairment of the indirect pathway of basal ganglia circuit.

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