Open AccessKidney and lung in pathology: mechanisms and clinical implications
Author(s) -
Ersilia Satta,
Carmelo Alfarone,
Alfonso De Maio,
S Gentile,
Carmine Romano,
Mario Polverino,
Francesca Polverino
Publication year - 2022
Publication title -
multidisciplinary respiratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 28
eISSN - 2049-6958
pISSN - 1828-695X
DOI - 10.4081/mrm.2022.819
Subject(s) - medicine , pathology , lung , cardiothoracic surgery , kidney , intensive care medicine , surgery
There is a close, physiological, relationship between kidney and lung that begin in the fetal age, and is aimed to keep homeostatic balance in the body. From a pathological point of view, the kidneys could be damaged by inflammatory mediators or by immune-mediated factors linked to a primary lung disease or, conversely, it could be the kidney disease that causes lung damage. Non-immunological mechanisms are frequently involved in renal and pulmonary diseases, as observed in chronic conditions. This crosstalk has clinical and therapeutic consequences. This review aims to describe the pulmonary-renal link in physiology and in pathological conditions.