Open AccessEvaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients
Author(s) -
Jasmina Obradović,
Vladimir Jurišić
Publication year - 2012
Publication title -
multidisciplinary respiratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 28
eISSN - 2049-6958
pISSN - 1828-695X
DOI - 10.4081/mrm.2012.639
Subject(s) - epidermal growth factor receptor , lung cancer , epidermal growth factor , mutation , cancer research , biology , lung , cancer , receptor , medicine , oncology , genetics , gene
Many different methods were developed to detect commonly known mutations and to screen new mutations of the epidermal growth factor receptor in non-small cell lung cancer patients. Some of these methods are so sensitive as to be able to detect even one epidermal growth factor receptor mutant tumor cell among up to 1000– 2000 normal cells. We have considered current methods chronologically reported to detect mutations in epidermal growth factor receptor in patients with non-small cell lung cancer. We also gave a short preview of their significance for routine clinical works. A Pub Med literature search was performed in order to demonstrate what methods are mostly used in mutation detection and to show their distribution through the last 10 years.