Open AccessAlveolar proteinosis in Behçet’s disease
Author(s) -
Cuneyt Tetikkurt,
Seza Tetikkurt,
Imran Ozdemir,
Çigdem Zuhur,
Nihal Bayar
Publication year - 2010
Publication title -
multidisciplinary respiratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 28
eISSN - 2049-6958
pISSN - 1828-695X
DOI - 10.4081/mrm.2010.644
Subject(s) - pulmonary alveolar proteinosis , medicine , bronchoalveolar lavage , pathology , eosinophilic , gastroenterology , lung
A 51-year-old man with Behçet’s disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL) revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS) stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte- macrophage colony stimulating factor (GM-CSF) antibody was negative. Recent studies have reported anti-GMCSF not present in the the serum of patients with secondary pulmonary alveolar proteinosis (PAP) but they have not reported so in patients with idiopathic PAP. We report a case of alveolar proteinosis in the setting of Behçet’s disease with spontaneous remission.