Bioactive isochromenone isolated from Aspergillus fumigatus, endophytic fungus from Bacopa monnieri | Zendy

Jay Prakash Thakur | Zendy; Rumana Haider | Zendy; D. K. Singh | Zendy; B. Sathish Kumar | Zendy; Prema G. Vasudev | Zendy; Suaib Luqman | Zendy; Alok Kalra | Zendy; Dharmendra Saikia | Zendy; Arvind S. Negi | Zendy

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Bioactive isochromenone isolated from Aspergillus fumigatus, endophytic fungus from Bacopa monnieri

Author(s) -

Jay Prakash Thakur,

Rumana Haider,

D. K. Singh,

B. Sathish Kumar,

Prema G. Vasudev,

Suaib Luqman,

Alok Kalra,

Dharmendra Saikia,

Arvind S. Negi

Publication year - 2015

Publication title -

microbiology research

Language(s) - English

Resource type - Journals

ISSN - 2036-7481

DOI - 10.4081/mr.2015.5800

Subject(s) - aspergillus fumigatus , bacopa monnieri , microbiology and biotechnology , plant use of endophytic fungi in defense , biology , botany

Fungal endophytes are a significant reservoir of novel bioactive secondary metabolites. Present communication describes isolation and structure determination of isochromenone, from endophytic microorganism Aspergillus fumigatus hosted in Bacopa monnieri plant. Further, its biological evaluation revealed it as antioxidant and antitubercular. The methanol extract of A . fumigatus inhibits the growth of the virulent strain of Mycobacterium tuberculosis H37RV with minimum inhibitory concentration 500 μg/mL. This is the first report of isolation of isochromenone from A. fumigatus.

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