Open AccessEffect of COVID-19 vaccination status on outcome of adult patients admitted at a tertiary care centre in India
Author(s) -
Bineet Ahluwalia,
Neeraj Gupta,
Amitabh Singh,
Pranav Ish,
Nishanth Dev,
Santvana Kohli,
Rohit Kumar,
Fellisha Marwein,
Nitesh Gupta
Publication year - 2022
Publication title -
monaldi archives for chest disease. pulmonary series/monaldi archives for chest disease/monaldi archives for chest disease. cardiac series
Language(s) - English
Resource type - Journals
eISSN - 2465-101X
pISSN - 1122-0643
DOI - 10.4081/monaldi.2022.2135
Subject(s) - medicine , vaccination , covid-19 , multivariate analysis , univariate analysis , tertiary care , pediatrics , immunology , outbreak , disease , virology , infectious disease (medical specialty)
COVID-19 vaccination was initially started in India on 16th January 2021 after approval from national authorities. This study was carried out to assess the effect of vaccination status on the severity and clinical outcome among patients infected with COVID-19. The study included all adult COVID-19 patients admitted to our hospital from 1st April to 30th June 2021. A total of 819 patients were enrolled in the study out of which only 183 (22.3%) were vaccinated. The study documented a statistically significant reduction in the severity of illness among the vaccinated (single/double dose) (33% severe COVID-19) against the unvaccinated (43% severe COVID-19) groups; along with a reduction in mortality. On univariate and multivariate analysis, age, severity of illness and lack of COVID-19 vaccination status were associated with a statistically significant increased mortality. To conclude, this study demonstrates the role of vaccination in decreasing the severity and mortality of COVID-19 infection.