Open AccessResistance training and sarcopenia
Author(s) -
Francesco Giallauria,
Antonio Cittadini,
Neil A. Smart,
Carlo Vigorito
Publication year - 2016
Publication title -
monaldi archives for chest disease. pulmonary series/monaldi archives for chest disease/monaldi archives for chest disease. cardiac series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 46
eISSN - 2465-101X
pISSN - 1122-0643
DOI - 10.4081/monaldi.2015.738
Subject(s) - sarcopenia , resistance training , muscle atrophy , atrophy , muscle mass , medicine , ageing , skeletal muscle , muscle strength , physical medicine and rehabilitation , strength training , psychological intervention , bioinformatics , physical therapy , endocrinology , biology , psychiatry
Aging is inexorably accompanied by a progressive decline of muscle mass, quality and strength. The resulting condition has been termed sarcopenia. Age-related sarcopenia can be accelerated by a variety of factors including changes in the hormonal milieu, inactivity, poor nutrition, chronic illness, and loss of integrity and function in the peripheral and central nervous systems. The downstream mechanisms by which these risk factors cause sarcopenia are not completely understood. Exercise training (particularly resistance training) has long been identified as the most promising method for increasing muscle mass and strength among older people. New interventions aimed at preventing muscle atrophy, promoting muscle growth and ultimately, maintaining muscle functions during aging are discussed. Understanding how age affects muscle-related gene expression, protein recycling and resynthesis, post-translational modification and turnover will be crucial to identify new treatment options