Open AccessAdipokines and coronary artery disease
Author(s) -
Teresa Strisciuglio,
Gennaro Galasso,
Dario Leosco,
Roberta De Rosa,
Giuseppe Di Gioia,
Valentina Parisi,
Stefania De Luca,
Tullio Niglio,
Chiara De Biase,
Rossella Luciano,
Giuseppe Rengo,
Bruno Trimarcö,
Federico Piscione
Publication year - 2015
Publication title -
monaldi archives for chest disease. pulmonary series/monaldi archives for chest disease/monaldi archives for chest disease. cardiac series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.196
H-Index - 46
eISSN - 2465-101X
pISSN - 1122-0643
DOI - 10.4081/monaldi.2012.117
Subject(s) - adipokine , paracrine signalling , autocrine signalling , coronary artery disease , adipose tissue , medicine , disease , endocrine system , pathological , pathogenesis , hormone , bioinformatics , biology , leptin , obesity , receptor
Adipose tissue, besides being an important energetic storage, is also a source of cytokines and hormones which act in a paracrine, autocrine and especially endocrine manner, influencing the cardiometabolic axis. Adipokines are a group of mediators with pleiotropic function, that are involved in many physiological processes, so that a disregulation in their secretion can lead to multiple pathological conditions. In this review our aim was to clarify the role of adipokines in the pathogenesis of atherosclerosis, especially in coronary artery disease, and based on current scientific evidence, to analyze the therapeutic and behavioral strategies that are so far available.