Open AccessDermatophytic infection and in vitro activities of antifungal drugs against dermatophytes in rural India
Author(s) -
Dharmendra Singh,
Ankita Sharma,
Rajesh Verma,
Satwant Kumar,
Satender Saraswat
Publication year - 2021
Publication title -
microbiologia medica
Language(s) - English
Resource type - Journals
eISSN - 2280-6423
pISSN - 1120-0146
DOI - 10.4081/mm.2021.9917
Subject(s) - terbinafine , trichophyton rubrum , medicine , itraconazole , dermatology , broth microdilution , ketoconazole , antifungal , trichophyton , antifungal drugs , dermatophyte , fluconazole , microbiology and biotechnology , biology , antibiotics , minimum inhibitory concentration
Background
Increase in resistance to conventional antifungals renders the need for antifungal sensitivity testing in Dermatophytes.
The present study aimed at determining the prevalence of dermatophytic infections and their susceptibility pattern in a rural healthcare facility.
Methods
Patients with suspected dermatophytosis attending the dermatology outpatient department were enrolled in the study. Specimen collection for mycological examinations was done. In-vitro antifungal sensitivity testing was performed as per the Clinical and Laboratory Standard Institute (CLSI) M38-A2 (2008) standards with broth microdilution method.
Results
Onychomycosis was the commonest (41.9%) presentation. Dermatophytic prevalence based on culture was 110 (70.9%). The commonest species was Trichophyton rubrum (36.8%). Terbinafine was found to be the most effective drug, followed by ketoconazole and itraconazole.
Conclusion
Antifungal sensitivity in dermatophytic infections should be made a routine in tertiary healthcare facilities as we are already witnessing the rampage of emerging fungal infection– Mucormycosis in the nation and worldwide.