Open AccessAntimicrobial susceptibility of enterococci from Italian patients with infective endocarditis
Author(s) -
Claudio Farina,
Giuseppe Russello,
Alfredo Raglio,
Francesca Vailati,
Veronica Ravasio,
Maria Bruna Pasticci,
Pierangelo Chinello,
Claudio Scarparo,
Gruppo Sei
Publication year - 2010
Publication title -
microbiologia medica
Language(s) - English
Resource type - Journals
eISSN - 2280-6423
pISSN - 1120-0146
DOI - 10.4081/mm.2010.2479
Subject(s) - fosfomycin , linezolid , tigecycline , infective endocarditis , ampicillin , enterococcus faecalis , microbiology and biotechnology , ceftriaxone , moxifloxacin , imipenem , medicine , antimicrobial , endocarditis , antibiotics , vancomycin , biology , staphylococcus aureus , antibiotic resistance , bacteria , genetics
The epidemiological and clinical study “Studio Endocarditi Italiane” (SEI) evaluated 947 cases of infective endocarditis in 2004-2008. Enterococcal aethiology was described in 11% cases.The aim of our study was to evacuate the in vitro activity of twelve antibiotics alone and in association against 20 strains (15 E. faecalis, 5 E. faecium). Results show the in vitro activity of tigecyicline, daptomicine and linezolid. Synergism is appreciated for ceftriaxone-fosfomycin (FICindex50=0.34, FICindex90=0.56) against E. faecalis and for imipenem-fosfomycin against E. faecium.The majority of the tested strains show addition using ampicillin-ceftriaxone (FICindex50=0.85, FICindex90=1.01) and moxifloxacin- tigecycline (FICindex50=0.77, FICindex90=1.96)