Open AccessLONG TERM NEURODEVELOPMENTAL OUTCOME IN A COHORT OF PRETERM INFANTS BORN AT GESTATIONAL AGE <32 WEEKS
Author(s) -
Maria Gabriella Gatti,
Serafina Perrone,
Silvia Badii,
Elisa Becucci,
Giovanni Turrisi,
Maria Gabriella Alagna,
E. Giacchi,
G Buonocore
Publication year - 2013
Publication title -
journal of the siena academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 2279-882X
pISSN - 2279-8811
DOI - 10.4081/jsas.2013.53
Subject(s) - bayley scales of infant development , toddler , gestational age , retinopathy of prematurity , medicine , pediatrics , cohort , motor skill , intraventricular hemorrhage , child development , cognition , psychology , pregnancy , developmental psychology , psychomotor learning , psychiatry , genetics , biology
Advances in perinatal care have led to an increase in survival of preterm children but have also increased the risk\udof long-term sequelae, like neurodevelopmental impairment and behavioral or emotional disturbance. To investigate neurodevelopmental\udpatterns of preterm infants born at S. Maria alle Scotte Hospital, Siena, Italy. 128 babies with gestational\udage (GA) ≤32 weeks were admitted in 2006-2008 to Siena Hospital; 105 infants survived and were followed until three years\udof age, corrected for prematurity. Neurodevelopmental follow up was performed using Bayley scale of Infant and Toddler\udDevelopment IIIed that consisted of five scales: Cognitive (CS), Language (LS), Motor (MS), Social-Emotional (SES) and\udAdaptive Behavior Scale (ABS). Intraventricular haemorrhage (IVH) was associated with lower motor score (P<0,001). Babies\udwith retinopathy of prematurity (ROP) showed a lower score in CS, LS, MS and SES Bayley’s items (respectively p≤0,01;\udp≤0,05; p≤0,01; p≤0,05). Multiple regression analysis indicated as predictors of neurological outcome: gestational age (GA)\udfor poor cognitive (p=0,016), language (p=0,004) and social-emotional development (p<0,0001), IVH for poor motor\ud(p<0,0001) and adaptive behavior development (p<0,0001), twinship for better language (p=0,001) and social-emotional development\ud(p=0,003). Bronchopulmoanry dyspasia (BPD) and patent ductus arteriosus (PDA) had a negative effect on respectively\udcognitive development (p=0,049) and social-emotional development (p=0,023). ROP, BPD, IVH, PDA, and GA\udsignificantly contributes to poor neurological outcome in preterm infants. BPD and IVH are the best predictors being associated\udwith the lowest scores at Bayley scales. Surprisingly, twinship appeared to be a protective factor