Open AccessSELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA
Author(s) -
Francesco Forconi,
Teresa Amato,
Elisa Sozzi,
Emanuele Cencini,
D. Raspadori,
Francesco Lauria
Publication year - 2012
Publication title -
journal of the siena academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 2279-882X
pISSN - 2279-8811
DOI - 10.4081/jsas.2009.18
Subject(s) - hairy cell leukemia , bone marrow , hairy cell , red pulp , immunoglobulin d , antibody , leukemia , marginal zone , immunoglobulin light chain , surface immunoglobulin , lymph node , b cell , pathology , chemistry , medicine , microbiology and biotechnology , cancer research , spleen , immunology , biology
Hairy cell leukemia (HCL) is a rare, chronic B-cell neoplasm characterized by leukemic hairy cells (HCs) present in blood, bone marrow, and splenic red pulp, with atrophy of white pulp. Lymph node involvement is infrequent. HCL is typically associated with markers of activation, that include expression of CD25, CD11c, FMC7, and CD103 at high intensity. A distinctive feature of HCL is expression of multiple surface immunoglobulin (sIg) isotypes, although its prevalence in HCL is not fully mapped