Open AccessSurvival of the fittest or best adapted: HLA-dependent tumor development
Author(s) -
Giuseppe Masucci,
Emilia Andersson,
Lisa Villabona,
Hildur Helgadóttir,
Kjell Bergfeldt,
Federica Cavallo,
Guido Forni,
Soldano Ferrone,
Aniruddha Choudhury,
Barbara Seliger,
Rolf Kiessling
Publication year - 2010
Publication title -
journal of nucleic acids investigation
Language(s) - English
Resource type - Journals
eISSN - 2035-6005
pISSN - 2036-7996
DOI - 10.4081/jnai.2010.e9
Subject(s) - survival of the fittest , human leukocyte antigen , biology , evolutionary biology , immunology , antigen
The major histocompatibility complex (MHC) comprises a set of genes that are critical to immunity and surveillance against neoplastic transformation. There is increasing evidence that the MHC antigens not only regulate antitumor immune responses in experimental animal models but directly correlate with survival and prognosis of patients with diverse types of cancers. MHC antigens may in the future function as potential biomarkers for prognosis and allow selection of cancer patients for intensive therapy