Survival of the fittest or best adapted: HLA-dependent tumor development | Zendy

Giuseppe Masucci | Zendy; Emilia Andersson | Zendy; Lisa Villabona | Zendy; Hildur Helgadóttir | Zendy; Kjell Bergfeldt | Zendy; Federica Cavallo | Zendy; Guido Forni | Zendy; Soldano Ferrone | Zendy; Aniruddha Choudhury | Zendy; Barbara Seliger | Zendy; Rolf Kiessling | Zendy

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Survival of the fittest or best adapted: HLA-dependent tumor development

Author(s) -

Giuseppe Masucci,

Emilia Andersson,

Lisa Villabona,

Hildur Helgadóttir,

Kjell Bergfeldt,

Federica Cavallo,

Guido Forni,

Soldano Ferrone,

Aniruddha Choudhury,

Barbara Seliger,

Rolf Kiessling

Publication year - 2010

Publication title -

journal of nucleic acids investigation

Language(s) - English

Resource type - Journals

eISSN - 2035-6005

pISSN - 2036-7996

DOI - 10.4081/jnai.2010.e9

Subject(s) - major histocompatibility complex , biology , human leukocyte antigen , immunology , immune system , antigen , histocompatibility , survival of the fittest , immunity , genetics

The major histocompatibility complex (MHC) comprises a set of genes that are critical to immunity and surveillance against neoplastic transformation. There is increasing evidence that the MHC antigens not only regulate antitumor immune responses in experimental animal models but directly correlate with survival and prognosis of patients with diverse types of cancers. MHC antigens may in the future function as potential biomarkers for prognosis and allow selection of cancer patients for intensive therapy

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