Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique | Zendy

Francesco Tessarolo | Zendy; R. Tatti | Zendy; Marco Molinari | Zendy; P. Dorigotti | Zendy; R. Antolini | Zendy; Giandomenico Nollo | Zendy

Open Access

Histochemical characterization of human osteochondral tissue: comparison between healthy cartilage, arthrotic tissues, and cartilage defect treated with MACI technique

Author(s) -

Francesco Tessarolo,

R. Tatti,

Marco Molinari,

P. Dorigotti,

R. Antolini,

Giandomenico Nollo

Publication year - 2011

Publication title -

journal of biological research - bollettino della società italiana di biologia sperimentale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.218

H-Index - 6

eISSN - 2284-0230

pISSN - 1826-8838

DOI - 10.4081/jbr.2011.4688

Subject(s) - cartilage , staining , proteoglycan , pathology , matrix (chemical analysis) , articular cartilage , extracellular matrix , anatomy , biomedical engineering , chemistry , medicine , biology , microbiology and biotechnology , osteoarthritis , alternative medicine , chromatography

Matrix-induced sutologous chondrocytes implantation (MACI) is a promising technique for the treatment of articular cartilage lesions, but long time outcome have to be established. We developed and optimized specific techniques of histochemical staining to characterize healthy and pathologic osteochondral tissue. Seven different staining protocols were applied to assess tissue architecture, cells morphology, proteoglycan content, and collagen fibers distribution. Potentialities of histochemical staining and histomorphology of biopsies from second look arthroscopy will be presented

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