A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia | Zendy

Rita Simone | Zendy; Claudya Tenca | Zendy; Franco Fais | Zendy; Giacomo De Rossi | Zendy; Giampaola Pesce | Zendy; Marcello Bagnasco | Zendy; Danièle Saverino | Zendy

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A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia

Author(s) -

Rita Simone,

Claudya Tenca,

Franco Fais,

Giacomo De Rossi,

Giampaola Pesce,

Marcello Bagnasco,

Danièle Saverino

Publication year - 2011

Publication title -

journal of biological research - bollettino della società italiana di biologia sperimentale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.218

H-Index - 6

eISSN - 2284-0230

pISSN - 1826-8838

DOI - 10.4081/jbr.2011.4665

Subject(s) - lymphoblastic leukemia , malignancy , pathogenesis , limiting , medicine , ctla 4 , immunology , leukemia , cancer research , t cell , immune system , mechanical engineering , engineering

CTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged

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