Open AccessA soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia
Author(s) -
Rita Simone,
Claudya Tenca,
Franco Fais,
Giacomo De Rossi,
Giancarlo Pesce,
Marcello Bagnasco,
Danièle Saverino
Publication year - 2011
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2011.4665
Subject(s) - limiting , pathogenesis , lymphoblastic leukemia , ctla 4 , immunology , malignancy , leukemia , cancer research , medicine , biology , t cell , immune system , mechanical engineering , engineering
CTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged