BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells | Zendy

Rossella Simone | Zendy; Andrea Rabellino | Zendy; Giancarlo Icardi | Zendy; Marcello Bagnasco | Zendy; Giampaola Pesce | Zendy; Daniel Olive | Zendy; Danièle Saverino | Zendy

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BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells

Author(s) -

Rossella Simone,

Andrea Rabellino,

Giancarlo Icardi,

Marcello Bagnasco,

Giampaola Pesce,

Daniel Olive,

Danièle Saverino

Publication year - 2011

Publication title -

journal of biological research - bollettino della società italiana di biologia sperimentale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.218

H-Index - 6

eISSN - 2284-0230

pISSN - 1826-8838

DOI - 10.4081/jbr.2011.4664

Subject(s) - proinflammatory cytokine , monocyte , microbiology and biotechnology , receptor , biology , immunology , inflammation , biochemistry

BT3, a new family of immunoreceptors, belongs to the extended B7 family. BT3 are expressed on the surface of resting and activated monocytes and monocytes-derived dendritic cells (iDC). We show that BT3 cross-linking, in the absence of other survival factors, provides a survival signal for monocytes. We further analysed the effects of BT3 cross-linking on various proinflammatory responses. Results obtained showed that BT3 engagements is able to modulate production of IL8/CXCL8, IL-I b and IL-I 2/p70. Moreover, we demostrated a co-stimulatory effect of BT3 receptors

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