Open AccessBT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells
Author(s) -
Rossella Emanuela Simone,
Andrea Rabellino,
Giancarlo Icardi,
Marcello Bagnasco,
Giampaola Pesce,
Daniel Olive,
Danièle Saverino
Publication year - 2011
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2011.4664
Subject(s) - proinflammatory cytokine , monocyte , microbiology and biotechnology , receptor , biology , immunology , inflammation , biochemistry
BT3, a new family of immunoreceptors, belongs to the extended B7 family. BT3 are expressed on the surface of resting and activated monocytes and monocytes-derived dendritic cells (iDC). We show that BT3 cross-linking, in the absence of other survival factors, provides a survival signal for monocytes. We further analysed the effects of BT3 cross-linking on various proinflammatory responses. Results obtained showed that BT3 engagements is able to modulate production of IL8/CXCL8, IL-I b and IL-I 2/p70. Moreover, we demostrated a co-stimulatory effect of BT3 receptors