Open AccessThe frequency of T regulatory cells is increased in peripheral blood of patients with colon-rectal cancer
Author(s) -
Danièle Saverino,
Cesare Stabilini,
Rita Simone,
Ezio Gianetta,
F. Milintenda-Florian
Publication year - 2011
Publication title -
journal of biological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.218
H-Index - 6
eISSN - 2284-0230
pISSN - 1826-8838
DOI - 10.4081/jbr.2011.4659
Subject(s) - immune system , immunosuppression , colorectal cancer , peripheral blood , immunology , medicine , cancer , il 2 receptor , antigen , cancer research , t cell
Immune system can recognise the tumor-associated antigens present in peripheal blood of cancer patients. Recent studies suggest that CD4+CD25+ regulatory T cells (Treg) might hamper effective immune-surveillance of cancer cells and impede effective immune responses to established tumours. The aim of this study is to demonstrate the presence of Treg in the peripheral blood of colon-rectal cancer (CRC) patients. Results indicate an increase frequency of Treg in the peripheral blood of CRC patients. In addition, Treg is able to regulate the in vitro proliferative response to CEA. Thus, these cells could regulate the immunosuppression and, eventually, the neoplastic progression in CRC patients