The frequency of T regulatory cells is increased in peripheral blood of patients with colon-rectal cancer | Zendy

Danièle Saverino | Zendy; Cesare Stabilini | Zendy; Rita Simone | Zendy; E Gianetta | Zendy; F. Milintenda-Florian | Zendy

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The frequency of T regulatory cells is increased in peripheral blood of patients with colon-rectal cancer

Author(s) -

Danièle Saverino,

Cesare Stabilini,

Rita Simone,

E Gianetta,

F. Milintenda-Florian

Publication year - 2011

Publication title -

journal of biological research - bollettino della società italiana di biologia sperimentale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.218

H-Index - 6

eISSN - 2284-0230

pISSN - 1826-8838

DOI - 10.4081/jbr.2011.4659

Subject(s) - colorectal cancer , immunosuppression , immune system , medicine , peripheral blood , il 2 receptor , immunology , cancer , antigen , regulatory t cell , cancer research , t cell

Immune system can recognise the tumor-associated antigens present in peripheal blood of cancer patients. Recent studies suggest that CD4⁺CD25⁺ regulatory T cells (Treg) might hamper effective immune-surveillance of cancer cells and impede effective immune responses to established tumours. The aim of this study is to demonstrate the presence of Treg in the peripheral blood of colon-rectal cancer (CRC) patients. Results indicate an increase frequency of Treg in the peripheral blood of CRC patients. In addition, Treg is able to regulate the in vitro proliferative response to CEA. Thus, these cells could regulate the immunosuppression and, eventually, the neoplastic progression in CRC patients

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